Proteins

Protein adsorption and structural changes

The z-LAB Instrument can provide researcher with new knowledge about the biological process that takes place when proteins are adsorbed to a surface, in terms of i.e., the strength of the protein-surface interactions as well as to sequential structural changes in an adsorbed protein film or displacement of charge or polar groups in the protein film.

Proteins denaturation, loss of 3D-structure, upon adsorption is governed by the type of interaction taking place between the protein and the surface. Hydrophobic (water-excluding) interactions between proteins and surface layers can be distinguished from more loosely bound proteins in native conformation using the z-LAB Instrument. Impedance measurement is independent of molecular mass but sensitive to structural and chemical properties of a molecular film, impedance measurements give important complementary information to mass-sensitive techniques.

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